The full Africa Synthesis, Analysis, Liquid Handling and FLLEX (SAHF) System enables entirely automated flow synthesis, analysis, aqueous work up, reagent injection and product collection.
The full Africa Synthesis, Analysis, Liquid Handling and FLLEX (SAHF) System is ideal for use in the following applications:
* Medicinal Chemistry
- Log D determination (fully automated)
- Library production (fully automated)
* Process Chemistry
- Log P determination (fully automated)
2 Syringe Pumps:
Flow rate 2.5ul to 2.5ml/min with pressure sensors and automatic over-pressure shutdown
4 Pressurized Input Bottles:
Regulated 1 bar Nitrogen or Argon is supplied to up to 4 bottles, eliminating cavitation and bubble formation and allowing the use of air sensitive reagents (requires laboratory gas supply).
Automatic Reagent Injection:
The RIM allows reagents stored on the robot deck to be automatically aspirated and loaded into one of 4 injection loops. The robot has a coaxial needle allowing the use of air sensitive reagents in vials. All timings are automatically managed, even for complex, multi-reactor systems. Samples are pre-pressurized before injection into the flowing stream.
All wetted parts are glass, PTFE or other similar fluoropolymer.
2 Temperature Controlled Microreactor Positions:
The Africa Heater/Cooler has two reaction positions, each of which can be factory set to either:
* 0°C – 150°C
* 40°C – 250°C
Flow Liquid-Liquid Extraction:
Flow extraction and separation of an extremely wide range of immiscible solvent pairs e.g. DCM:Aq, Ethyl Acetate:Aq, THF:Aq, Ether:Aq etc. (where Aq is aqueous).
The Sampler and dilutor takes a 5ul sample from the flowing stream, dilutes it by up to 250 fold and injects it onto an analytical system e.g. HPLC, LCMS, UPLC etc.
The Africa HPLC allows integrated synthesis conditions an HPLC traces.
Automated Product Collection:
Each different reaction is automatically collected in a different
The full Africa Synthesis, Analysis, Liquid Handling and FLLEX (SAHF) contains the following modules:
Description Part Number
Microreactors - Various
Tube Reactors - Various
2 Reagent Pumps - 2100140
Heater/Cooler - 2100090
Pressurisation Module - 2110701
Product Collection Module - 2100806
Sampler and Dilutor - 2100389
HPLC Pumps - 2100388
UV Detector - 2100391
Solvent Store - 2100390
Reagent Injection Module - 2101431
FLLEX Module - 2100700
Tube Reactor Heater (Optional) - 2100640
Laptop and Software - 2110724
Synthesis Pack - 2110714
Analysis Pack - na