The Synthesis, Analysis and Liquid Handling (SAH) System enables entirely automated flow synthesis, analysis, reagent injection and product collection
The Synthesis, Analysis and Liquid Handling (SAH) System is ideal for use in the following applications:
* Medicinal chemistry
- Method development (fully automated)
- Library production (fully automated)
* Process chemistry
- Reaction optimisation (fully automated)
- Route scouting (fully automated)
4 Syringe Pumps:
Flow rate 2.5µl to 2.5ml/min with pressure sensors and automatic over-pressure shutdown
4 Pressurized Input Bottles:
Regulated 1 bar Nitrogen or Argon is supplied to up to 4 bottles, eliminating cavitation and bubble formation and allowing the use of air sensitive reagents (requires laboratory gas supply).
Automatic Reagent Injection:
The RIM allows reagents stored on the robot deck to be automatically aspirated and loaded into one of 4 injection loops. The robot has a coaxial needle allowing the use of air sensitive reagents in vials. All timings are automatically managed, even for complex, multi-reactor systems. Samples are pre-pressurized before injection into the flowing stream.
All wetted parts are glass, PTFE or other similar fluoropolymer.
2 Temperature Controlled Microreactor Positions:
The Africa Heater/Cooler has two reaction positions, each of which can be factory set to either:
* 0°C – 150°C
* 40°C – 250°C
The Sampler and dilutor takes a 5µl sample from the flowing stream, dilutes it by up to 250 fold and injects it onto an analytical system e.g. HPLC, LCMS, UPLC etc.
The Africa HPLC allows integrated synthesis conditions an HPLC traces.
Automated Product Collection:
Each different reaction is automatically collected in a different vial. The vial (or vessel) size is set by the user. Reactions larger than the vial size are automatically collected across multiple vials or preparative quantities can be collected in large one vessel.
The Africa software allows an almost unlimited number of reactor configurations and automates the entire process. Only “chemist friendly” data such as volumes, times and temperatures need to be added – no need to deal with flow rates if you don’t want to. The timings of all events such as pumps starting, injections, collections etc. are all automatically calculated and performed automatically.
The Synthesis, Analysis and Liquid Handling (SAH) System contains the following modules:
Description Part Number
Microreactors - Various
Tube Reactors - Various
2 Reagent Pumps - 2100140
Heater/Cooler - 2100090
Pressurisation Module - 2110701
Product Collection Module - 2100806
Sampler and Dilutor - 2100389
HPLC Pumps - 2100388
UV Detector - 2100391
Solvent Store - 2100390
Reagent Injection Module - 2101431
Tube Reactor Heater (Optional) - 2100640
Laptop and Software - 2110724
Synthesis Pack - 2110714
Analysis Pack - na