The Synthesis and FLLEX (SF) System enables pressurised flow reactions with 4 independently controlled substrate/reagent inputs, two independently temperature controlled reaction locations and aqueous work-up.
The Synthesis and FLLEX (SF) System is ideal for use in the following applications:
* Medicinal chemistry
- Log D determination (controlled chemistry)
* Process chemistry
- Log P determination (controlled chemistry)
4 Syringe Pumps:
Flow rate 2.5µl to 2.5ml/min with pressure sensors and automatic over-pressure shutdown
4 Pressurized Input Bottles:
Regulated 1 bar Nitrogen or Argon is supplied to up to 4 bottles, eliminating cavitation and bubble formation and allowing the use of air sensitive reagents (requires laboratory gas supply).
4 Manual Injection Loops and Valves:
1ml, 5ml or 10ml loops
Chemical Resistance –
All wetted parts are glass, PTFE or other similar fluoropolymer.
2 Temperature Controlled Microreactor Positions:
The Africa Heater/Cooler has two reaction positions, each of which can be factory set to either:
* 0°C – 150°C
* 40°C – 250°C
Flow Liquid-Liquid Extraction:
Flow extraction and separation of an extremely wide range of immiscible solvent pairs e.g. DCM:Aq, Ethyl Acetate:Aq, THF:Aq, Ether:Aq etc. (where Aq is aqueous).
The Africa software allows an almost unlimited number of reactor configurations and automates the entire process. Only “chemist friendly” data such as volumes, times and temperatures need to be added – no need to deal with flow rates if you don’t want to. The timings of all events such as pumps starting, injections, collections etc. are all automatically calculated and performed automatically.
The Africa 4 Channel Synthesis System (S) contains the following modules:
Description Part Number
Microreactors - Various
Tube Reactors - Various
2 Reagent Pumps - 2100140
Heater/Cooler - 2100090
Reagent Store - 2100150
Pressurisation Module - 2110701
FLLEX Module - 2100700
Tube Reactor Heater (Optional) - 2100640
Laptop and Software - 2110724
Synthesis Pack - 2110714